William A. Howard
Research Description
Research in my laboratory is focused on synthetic and mechanistic transition metal chemistry. My research interests include (1) creating transition metal — based drugs for treating the symptoms of malignant diseases, and (2) rigorously studying the chemical behavior of a particular transition metal in order to understand better the general principles governing the outcomes of chemical reactions. This work often requires the use of an inert atmosphere glovebox, a high vacuum line, and Schlenk techniques.
Currently there are two research projects based on these interests that are ongoing in my lab. The first project involves preparing and characterizing new vanadium complexes and testing selected samples as insulin mimics. The second project involves preparing and characterizing new rhodium complexes in order to learn more of the coordination chemistry of this metal.
Selected Publications
- "Anticancer Activity as a Function of Ligand Isomerism in the Series Pt(CH3)2I2{2,2'-bipyridine-n,
n'-(CH3)2} (n,n' = 4,4'; 5,5'; and 6,6')." Stitz, Shadrach; Howard, William A.; Wheeler, Kraig A. Manuscript in Preparation. - "Synthesis, Structure, and Anticancer Activity of a Dinuclear Organoplatinum(IV) Complex Stabilized by Adenine." O'Brien, Alisha M.; Wheeler, Kraig A.; Howard, William A. Compounds 2025, 5, 16-27.
- "Anticancer Activity of Nonpolar Pt(CH3)2I2{bipy} Is Found to be Superior among Four Similar Organoplatinum(IV) Complexes." Arabi, Ameneh; Cogley, Marcus O.; Fabrizio, Daniel; Stitz, Shadrach; Howard, William A.; Wheeler, Kraig A. J. Mol. Struct. 2023, 1274, 134551.
Education
- Postdoc 1997, University of California Berkeley (Organometallic Chemistry)
- Ph.D. 1995, Columbia University (Inorganic Chemistry)
- B.S. 1990, Tulane University (Chemistry)
Contact
Phone: 907-474-6019
Fax: 907-474-5640
Email: wahoward@alaska.edu
Address:
William A. Howard
Department of Chemistry & Biochemistry
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²ÊÉñix¹ÙÍø, AK 99775-6160